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Search content: Drug = ABI-009
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Gene | Variant | Type | Tumor | Drug | Drug level | Reference | More |
---|---|---|---|---|---|---|---|
TSC2 | Oncogenic Mutations | MUT | Perivascular Epithelioid Cell Tumor | ABI-009 | II | 2 | |
Evidence region
OncoKB Patient Criteria- Note- Gene name
Full name
TSC complex subunit 2 Gene typeprotein-coding FunctionMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Sorry, there is no related drug information. |
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