Result
Gene | Variant | Type | Tumor | Drug | Drug level | Reference | More |
---|---|---|---|---|---|---|---|
BRCA1 | Oncogenic Mutations | MUT | All Solid Tumors | ABT-767 | II | 1 | |
Evidence region
Literature Patient CriteriaAdvanced type NoteGilteritinib was well tolerated and demonstrated antileukemic activity in a Japanese R/R AML population. Gene name
Full name
BRCA1 DNA repair associated Gene typeprotein-coding FunctionThis gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020] Sorry, there is no related drug information. |
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BRCA2 | Oncogenic Mutations | MUT | All Solid Tumors | ABT-767 | II | 1 | |
Evidence region
Literature Patient CriteriaAdvanced type NoteGilteritinib was well tolerated and demonstrated antileukemic activity in a Japanese R/R AML population. Gene name
Full name
BRCA2 DNA repair associated Gene typeprotein-coding FunctionInherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020] Sorry, there is no related drug information. |