Result
Gene | Variant | Type | Tumor | Drug | Drug level | Reference | More |
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APC | Oncogenic Mutations | MUT | Colon Cancer | Tankyrase inhibitors | V | 2 | |
Evidence region
CGI Patient Criteria- NoteIn this work, we have identified a novel TNKS inhibitor, JW55, which inhibits the PARP domain of TNKS1/2, leading to the stabilization of AXIN2 followed by increased degradation of b-catenin. JW55 efficiently decreases canonical Wnt signaling in colon carcinoma cell lines, in a Xenopus axis duplication assay, and in tamoxifen-induced tumors in ApcCKO/CKOLgr5-CreERT2+ mice. The identified chemotype JW55 may serve as an attractive start point for the development of novel cancer therapeutics. Gene name
Full name
APC regulator of WNT signaling pathway Gene typeprotein-coding FunctionThis gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019] Sorry, there is no related drug information. |
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APC | Oncogenic Mutations | MUT | Colon Cancer | G007-LK | V | 1 | |
Evidence region
CIVIC Patient Criteria- NoteG007-LK inhibits in vivo tumor growth in a subset of APC-mutant colorectal cancers xenograft models but may be limited by intestinal toxicity. Gene name
Full name
APC regulator of WNT signaling pathway Gene typeprotein-coding FunctionThis gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019] Sorry, there is no related drug information. |
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APC | Oncogenic Mutations | MUT | Colon Cancer | JW55 | V | 1 | |
Evidence region
CIVIC Patient Criteria- NoteCanonical Wnt signaling in colon carcinoma cells with APC mutation was inhibited by JW55 treatment. Gene name
Full name
APC regulator of WNT signaling pathway Gene typeprotein-coding FunctionThis gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019] Sorry, there is no related drug information. |