|FOXO1||FOXO1-PAX3||FUS||Alveolar Rhabdomyosarcoma||BET inhibitors||V||1|
5 PAX3-FOXO1 fusion positive rhabdomyosarcoma cell lines exhibited greater sensitivity to BET bromodomain inhibitors than fusion negative lines and introduction of the PAX3-FOXO1 fusion to fibroblasts was sufficient to drive an 11 fold increase in sensitivity. The BET inhibitor JQ1 was efficacious in a PAX3-FOXO1 xenograft model.
Gene name Full name
forkhead box O1Gene type
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Sorry, there is no related drug information.